Pipeline
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KeifeRx is building upon its extensive clinical experience in neurodegenerative diseases to advance a second generation of orally delivered small molecules that demonstrate high blood-brain-barrier penetration, selective kinase inhibition, and enhanced clearance of toxic protein buildup associated with neurodegenerative disease. Additionally, selective inhibition of kinases related to mast cell-mediated inflammatory conditions has the potential to reduce symptoms for patients suffering from immune conditions.
Nilotinib
Alzheimer's Disease
Target(s) : c-ABL, c-KIT, FYN
Discovery
Pre-clinical
IND-Enabling
Ph 1
Ph 2
Parkinson's Disease & Dementia
KFRX04
c-ABL, DDR-1
Target(s) : c-KIT, PIKFYVE
KFRX05
Amyotrophic lateral sclerosis (ALS)
Mast Cell Activated Syndrome (MCAS)
Urticaria
Target(s) : c-KIT (mutants), LRRK2
Parkinson's Disease Dementia (PDD)
KFRX06
Parkinson's disease (LRRK2 mutant)
Target(s) : c-KIT (mutants)
Frontotemporal dementia
KFRX06
c-KIT (mutants)
Frontotemporal Dementia
Parkinson's Disease (LRRK2 Mutant)
KFRX05
c-KIT (mutants), LRRK2
Parkinson's Disease Dementia
Mast Cell Activated Syndrome
Urticaria
KFRX04
c-KIT, PIKFYVE
Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
c-ABL, c-KIT, FYN
KFRX03
Alzheimer's Disease
c-ABL, DDR-1
Parkinson's Disease Dementia